Cerebral Blood Flow: Mechanisms of Ischemia, Diagnosis, and Therapy
Cerebral Blood Flow: Quantifying Consciousness Although the heart may be the source of energy needed to generate blood flow,and other organs absolutely essential for normal living,the brain is the reason we are alive. The collected book chapters are aimed at addressing this most fundamental organ and its blood flow. These papers reflect detailed descriptions of similar topics presented over a two-day period as part of the 5th International Symposium on Applied Physiology of the Peripheral Circulation held in Pittsburgh, Pennsylvania, in June 2000. The symposium and this volume were organized into four distinct groupings that follow in a logical fashion. The initial papers focus on the basic unique physiology and pathophysiology of the cerebral circulation, including a historical reviewof the means to measure cerebral blood flow and its implications of the past 30 years. Dr. Walter D. Obrist was one of the original investigators to use radiolabeled markers to assess cerebral blood flow. His equations and initial studies form an impressive introduction to where we are now. As with much of the body's special organs, the brain too has many circulatory features unique to itself.These include the unique blood-brain barrier function ofthe endothelium, local neural regulation control, and intracranial pressure effects. These special issues,plus genetic factors that may predispose individuals to developing cere bral aneurysm, make up the initial section of the monograph.
Table of contents : Front Matter....Pages i-xv
Front Matter....Pages 1-1
History of Cerebral Blood Flow Assessment....Pages 3-6
Neural Regulation of the Cerebral Circulation....Pages 7-16
Role of Endothelium in Regulation of the Brain Microcirculation....Pages 17-25
Molecular Pathogenesis of Cerebral Aneurysms: Current Concepts and Future Directions....Pages 26-41
Front Matter....Pages 43-43
Triggering Events in Ischemic Brain Damage....Pages 45-59
Ischemic Mechanisms in Traumatic Brain Injury....Pages 60-71
Coupling and Compartmentation of Cerebral Blood Flow and Metabolism....Pages 72-95
The Genetic Control of Ischemic Neuronal Cell Death....Pages 96-105
Cerebral Resuscitation from Temporary Complete Global Brain Ischemia....Pages 106-136
The Ischemic Penumbra: Pathophysiology and Therapeutic Implications....Pages 137-146
Front Matter....Pages 147-147
The Assessment of Determinants of Cerebral Oxygenation and Microcirculation....Pages 149-164
Computed Tomography Angiography and Perfusion Imaging of Acute Stroke....Pages 165-178
The Use of Xenon/CT Cerebral Blood Flow Studies in Acute Stroke....Pages 179-190
Advances in Imaging in Ischemic Stroke....Pages 191-200
Assessment of Cerebrovascular Pathophysiology....Pages 201-216
Cerebral Blood Flow Measurement with Positron Emission Tomography....Pages 217-225
Front Matter....Pages 227-227
Thrombolysis for Acute Stroke....Pages 229-235
Neuroprotective Stroke Trials: A Ten Year Dry Season....Pages 236-251
Interventional Neuroradiology in Acute Ischemic Stroke; Extracranial and Intracranial Angioplasty and Stenting....Pages 252-271
Therapeutic Moderate Hypothermia and Fever....Pages 272-276
Front Matter....Pages 227-227
Cerebral Hemodynamics and Stroke Risk in Patients with Complete Carotid Artery Occlusion: Is There a Role for Cerebral Revascularization?....Pages 277-297
Cerebral Blood Flow: Quantifying Consciousness Although the heart may be the source of energy needed to generate blood flow,and other organs absolutely essential for normal living,the brain is the reason we are alive. The collected book chapters are aimed at addressing this most fundamental organ and its blood flow. These papers reflect detailed descriptions of similar topics presented over a two-day period as part of the 5th International Symposium on Applied Physiology of the Peripheral Circulation held in Pittsburgh, Pennsylvania, in June 2000. The symposium and this volume were organized into four distinct groupings that follow in a logical fashion. The initial papers focus on the basic unique physiology and pathophysiology of the cerebral circulation, including a historical reviewof the means to measure cerebral blood flow and its implications of the past 30 years. Dr. Walter D. Obrist was one of the original investigators to use radiolabeled markers to assess cerebral blood flow. His equations and initial studies form an impressive introduction to where we are now. As with much of the body's special organs, the brain too has many circulatory features unique to itself.These include the unique blood-brain barrier function ofthe endothelium, local neural regulation control, and intracranial pressure effects. These special issues,plus genetic factors that may predispose individuals to developing cere bral aneurysm, make up the initial section of the monograph.
Table of contents : Front Matter....Pages i-xv
Front Matter....Pages 1-1
History of Cerebral Blood Flow Assessment....Pages 3-6
Neural Regulation of the Cerebral Circulation....Pages 7-16
Role of Endothelium in Regulation of the Brain Microcirculation....Pages 17-25
Molecular Pathogenesis of Cerebral Aneurysms: Current Concepts and Future Directions....Pages 26-41
Front Matter....Pages 43-43
Triggering Events in Ischemic Brain Damage....Pages 45-59
Ischemic Mechanisms in Traumatic Brain Injury....Pages 60-71
Coupling and Compartmentation of Cerebral Blood Flow and Metabolism....Pages 72-95
The Genetic Control of Ischemic Neuronal Cell Death....Pages 96-105
Cerebral Resuscitation from Temporary Complete Global Brain Ischemia....Pages 106-136
The Ischemic Penumbra: Pathophysiology and Therapeutic Implications....Pages 137-146
Front Matter....Pages 147-147
The Assessment of Determinants of Cerebral Oxygenation and Microcirculation....Pages 149-164
Computed Tomography Angiography and Perfusion Imaging of Acute Stroke....Pages 165-178
The Use of Xenon/CT Cerebral Blood Flow Studies in Acute Stroke....Pages 179-190
Advances in Imaging in Ischemic Stroke....Pages 191-200
Assessment of Cerebrovascular Pathophysiology....Pages 201-216
Cerebral Blood Flow Measurement with Positron Emission Tomography....Pages 217-225
Front Matter....Pages 227-227
Thrombolysis for Acute Stroke....Pages 229-235
Neuroprotective Stroke Trials: A Ten Year Dry Season....Pages 236-251
Interventional Neuroradiology in Acute Ischemic Stroke; Extracranial and Intracranial Angioplasty and Stenting....Pages 252-271
Therapeutic Moderate Hypothermia and Fever....Pages 272-276
Front Matter....Pages 227-227
Cerebral Hemodynamics and Stroke Risk in Patients with Complete Carotid Artery Occlusion: Is There a Role for Cerebral Revascularization?....Pages 277-297
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